Uric acid and xanthine oxidase: perspectives in chronic heart failure
نویسندگان
چکیده
Heart failure continues to be one of the major causes of morbidity and mortality in the western world. Advances in cardiovascular medicine have lead to unearth the possible markers of disease progression. Hyperuricemia is one of the potential metabolic markers for heart failure. In this review, we discuss the beneficial and deleterious role of uric acid and xanthine oxidase in the pathophysiology and management of chronic heart failure. Measurement of this readily available inexpensive marker may be included in the routine protocol and xanthine oxidase inhibition in addition to correct hyperuicemia may improve the vascular function and oxidative stress in patients with chronic heart failure.
منابع مشابه
Invited commentary Uric acid in chronic heart failure: marker or therapeutic target? Commentary on Uric acid and xanthine oxidase: perspectives in chronic heart failure
Heart failure is one of the leading medical problems in modern medicine regardless of whether we view it from the clinical, prognostic, epidemiological or socio-economic perspective. While current treatment strategies are targeting exclusively the neurohormonal activation, our pathophysiologic understanding has advanced significantly towards an increasingly complex picture including metabolic, ...
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